Environmental & Analytical Toxicology

Mahmoud El-Sherbiny

Publications

• Research Article
  Protective Effect of a Synthetic Antioxidant "Acetyl Gallate Derivative" Against Dimethoate Induced DNA Damage and Oxidant/Antioxidant Status in Male Rats
  Author(s): Tarek M. Heikal, Abdel-Tawab H. Mossa, Galal A. M. Nawwar, Mahmoud El-Sherbiny and Hassan Z. GhanemTarek M. Heikal, Abdel-Tawab H. Mossa, Galal A. M. Nawwar, Mahmoud El-Sherbiny and Hassan Z. Ghanem
  
  The present study was conducted to investigate the protective effects of a synthetic antioxidant “acetyl gallate derivative” (SAC) against hepatic oxidative stress and brain DNA damage induced by dimethoate (DM) in male rats. DM was orally administrated to the rats at a dose of 38.7 mg kg-1 b.wt. (1/10 LD50), for 28 consecutive days. Additional DM groups received either SAC or vitamin C (VC) at a dose of 200 mg kg-1 b.wt. 30 min before DM administration. Compared to the control, DM induced a statistical reduction in body weight gain, while induced a statistical increase in absolute and relative liver weights. Oral administration of DM significantly caused increases in hepatic lipid peroxidation (LPO) and activities of antioxidant enzymes including catalase (CAT), superoxide dismutase (SOD) and glutathione-s-transferease (GST), while caused decreases in glutathione content .. Read More»
  DOI: 10.4172/2161-0525.1000155

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