Journal of Health & Medical Informatics

MAIGRET Bernard

Publications

• Research Article
  HIV-PDI: A Protein-Drug Interaction Resource for Structural Analyses of HIV Drug Resistance: 1. Concepts and Associated Database
  Author(s): GHEMTIO Leo, SMAÏL-TABBONE Malika, DJIKENG Appolinaire, DEVIGNES Marie-Dominique, KEMINSE Lionel, KELBERT Patricia, FOKAM Joseph, MAIGRET Bernard and OUWE-MISSI-OUKEM-BOYER OdileGHEMTIO Leo, SMAÏL-TABBONE Malika, DJIKENG Appolinaire, DEVIGNES Marie-Dominique, KEMINSE Lionel, KELBERT Patricia, FOKAM Joseph, MAIGRET Bernard and OUWE-MISSI-OUKEM-BOYER Odile
  
  Overcoming the problem of resistance to antiretroviral drugs (ARVs) in HIV-infected patients is a major issue in AIDS research today. Advances in genome sequencing have facilitated the identification of a growing number of individual genotypes. Hence, it is now possible to understand HIV drug resistance at the molecular level by considering the three-dimensional (3D) structural interactions between ARVs and the mutated viral proteins of patients. Therefore, identification of the critical interactions lost further to one or several HIV mutations, and consequently the modifications of other molecular factors, could be indicators to propose appropriate ARVs escaping the resistance. This paper introduces the HIV-PDI (Protein-Drug Interactions) resource designed to be a decision making tool to propose alternative ARVs against a particular mutated viral protein, and thus to provide a person.. Read More»
  DOI: 10.4172/2157-7420.1000104

  Abstract PDF