Journal of Clinical Case Reports

Maisa Mahmoud Ali

Publications

• Case Report
  Mutation Patterns at Codons Rt204 And Rt180 of the HBV Polymerase Gene Associated with Lamivudine Resistance in Treated and Untreated Chronic HBV Patients in Kuwait: A Case Series
  Author(s): Maisa Mahmoud Ali, Fuad Hasan, Suhail Ahmad, Siham Al- Mufti, Haifa Asker, Salem Farhan and Widad Al- NakibMaisa Mahmoud Ali, Fuad Hasan, Suhail Ahmad, Siham Al- Mufti, Haifa Asker, Salem Farhan and Widad Al- Nakib
  
  Introduction: Lamivudine is a potent inhibitor of hepatitis B virus (HBV) replication via suppression of the RNAdependent DNA polymerase. However, patients with prolonged therapy were previously detected harboring drugresistant mutants. Such mutants though partially replication defective, confer resistance to lamivudine and can elicit exacerbation of hepatonecro-inflammation. Cases presentation: In this case series, we examined mutations in the YMDD motif gene in five lamivudinetreated patients (60 yr male, 50 yr female, 46 yr male, 36 yr male and 42 yr male) and in four untreated patients (34 yr female, 29 yr male, 29 female and 37 yr male). Rare mutational patterns of rtM204L in conjunction with rtL108M were recognized conferring resistance to lamivudine. The rtL180M compensatory mutation was identified in conjunction with rtM204V/I/L; among which three patients had viral and bioche.. Read More»
  DOI: 10.4172/2165-7920.1000276

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