Molecular Biology: Open Access

Malathi Ragunathan

Publications

• Research Article
  Evaluation of Antiangiogenic Potential of MMP₂ Antisense Oligonucleotide for the Management of Proliferative Diabetic Retinopathy Using Chicken Chorioallantoic Membrane
  Author(s): Reji Manjunathan and Malathi RagunathanReji Manjunathan and Malathi Ragunathan
  
  Proliferative diabetic retinopathy (PDR) is the advanced stage of diabetic retinopathy in which neovascularization occurs at the retina. Angiogenesis, the formation of new vessels from the existing one involves sequential step starting from the degradation of basement membrane by matrix metalloproteinases (MMPs). The elevated expression of MMP2 is considered as the one of the important parameter in the progress of PDR. Therefore, it is important to inhibit the activity of MMP2 in the retina of the PDR patients for the management of the diseases. In this concern we examined the anti angiogenic potential of antisense MMP2 oligonucleotide using chicken late CAM (chorio allantoic membrane) using various techniques. CAM has been used as a model for retinal research by ophthalmologist for many years due to its similarities with retina in the tissue thickness and blood vessels formation. MMP.. Read More»
  DOI: 10.4172/2168-9547.1000148

  Abstract PDF