Journal of Cytology & Histology

Manar Hamed Arafa

Publications

• Research Article
  The Effects of Monosodium Glutamate on Thymic and Splenic Immune Functions and Role of Recovery (Biochemical and Histological study)
  Author(s): Zeinab A. Hassan, Manar Hamed Arafa, Wafaa Ibrahim Soliman, Hebatallah Husseini Atteia and Hanan Fathy Al-SaeedZeinab A. Hassan, Manar Hamed Arafa, Wafaa Ibrahim Soliman, Hebatallah Husseini Atteia and Hanan Fathy Al-Saeed
  
  Monosodium glutamate (MSG), a flavor enhancer, is used in modern nutrition to improve food palatability. The objectives of the current study were to investigate the effect of MSG on thymus as well as spleen structures and functions. Also, to evaluate the possibility of recovery after cessation of administration. Adult male rats were divided into three groups: control, MSG (3 g MSG/kg body weight daily for 8 weeks by oral gavages), and Recovery (MSG for same period and then left untreated for additional 4 weeks). The results showed that MSG treatments significantly increased serum interleukin (IL)-1β as well as thymic and splenic malondialdehyde and decreased serum levels of IL-10 and also reduced glutathione (GSH) levels and both catalase and superoxide dismutase activities in the thymus and spleen. Histological examination showed that MSG induced a remarkable disruption in the l.. Read More»
  DOI: 10.4172/2157-7099.1000283

  Abstract PDF