Journal of Computer Science & Systems Biology

Manish Kumar Gupta

Publications

• Research Article
  Metabolic Modeling and Simulation Analysis of Thyroid Disorder Pathway
  Author(s): Manish Kumar Gupta, Dev Bukhsh Singh, S. K. Rath and Krishna MisraManish Kumar Gupta, Dev Bukhsh Singh, S. K. Rath and Krishna Misra
  
  Thyroid hormone secretion pathway is one of the important pathways that regulates growth, development and is considered critical for brain, skeletal development and maturation. Autoimmune Thyroid Disease (AITD) results in damage of the thyroid gland altering the normal secretion of thyroid hormones causing hypothyroidism (Hashimoto’s thyroiditis) or hyperthyroidism (graves’ disease). A map of molecular interaction of the thyroid stimulating hormone receptor has been created using systems biology graphical notation language with the help of CellDesigner 4.1 and converted into BioPax 2.8.2 pathways description format. In the current state the map contains 9 compartment, 32 simple and complex protein, 18 small molecules, 3 ions and 35 chemical reactions. The network contains more details about Thyroid hormones, Thyroxin (T4) and Triiodothyronin (T.. Read More»
  DOI: 10.4172/jcsb.1000090

  Abstract PDF