Nuclear Medicine & Radiation Therapy

Manoj Gupta

Publications

• Review Article
  Is PSMA PET-CT Better than Bone Scan? When and Why
  Author(s): Manoj Gupta, Partha Sarathi Choudhury, Harish Chandra Goel, Sudhir Rawal and Vineet TalwarManoj Gupta, Partha Sarathi Choudhury, Harish Chandra Goel, Sudhir Rawal and Vineet Talwar
  
  Prostate cancer (PCa) has a unique tropism to bone. Indeed, bone is the most frequent site of distant metastasis and cause of morbidity due to skeletal complications. 99mTc-Methylene diphosphonate (MDP) bone scintigraphy/ scan (BS) is the current standard imaging due to increase adsorption of the tracer at osteoblastic sites. However, it has limited specificity due to false positives in degenerative changes, benign causes and false negatives in bone marrow metastasis and lytic lesions. Another drawback of BS is flare response. Prostate Specific Membrane Antigen (PSMA) has been the most studies target in prostate cancer imaging in recent time due to 100-1000 time overexpression in cancer cells. 68Ga-PSMA-11, a small molecule with PSMA enzyme inhibition activity has been found promising in recurrence and lymph-node staging. In our experience of 97 staging prostate cancer patients, PSMA .. Read More»
  DOI: 10.4172/2155-9619.1000342

  Abstract PDF