Nuclear Medicine & Radiation Therapy

Marcel Kap

Publications

• Research Article
  Radiolabeled Immunoglobulin Therapy for Patients with Solid Tumors
  Author(s): Nabil Khater, Marcel Kap, Rima Sayah, Dimor Elbers and Huib M VriesendorpNabil Khater, Marcel Kap, Rima Sayah, Dimor Elbers and Huib M Vriesendorp
  
  Purpose: To test the reactivity of monoclonal murine IgM and IgG for Tenascin-C (TNC) in formalinized solid human tumors tissue samples and to estimate the radiation dose that Yttrium- 90 labeled murine IgM reactive with TNC can deliver to a solid tumor and tumor containing draining lymph nodes. Materials and Methods: Using Immunohistochemistry (IHC), mouse anti-human TNC IgM and IgG clones were tested for the detection of TNC in formalin fixed biopsies of patients with Glioblastoma multiforme (GBM), adeno carcinoma of the exocrine pancreas (PaCa)-, breast-, colon-, renal-, ovary- prostate carcinoma, cutaneous-, ocular- melanomas, and Ewing Sarcoma. IHC was performed on all tumors with an n=1, except for PaCa and ocular melanomas, n=11. Monte-Carlo simulation and convolution calculations were used to determine the activity of Y-90 required f.. Read More»
  DOI: 10.4172/2155-9619.1000338

  Abstract PDF