Veterinary Science & Technology

Maria Teresa Rugeles

Publications

• Research Article
  Bovine Fibroblasts Response to Foot-and-Mouth Disease Virus: Influence of Integrins and Soluble Factors in Resistance
  Author(s): Julian Ruiz-Saenz, Jorge E Ossa, José Barrera, Maria Teresa Rugeles and Albeiro López-HerreraJulian Ruiz-Saenz, Jorge E Ossa, José Barrera, Maria Teresa Rugeles and Albeiro López-Herrera
  
  Foot and mouth disease may be the most economically devastating animal disease nowadays. Blanco Orejinegro (BON) cattle are one of the native creole breeds from Colombia; this breed carries important genetic traits for survival and reproduction in the tropics showing in vitro and in vivo resistance to pathogens. Here we evaluate primary fibroblast cultures of BON cattle for their phenotypic resistence/susceptibility (R/S) polymorphism toward FMDV, and to determine whether a correlation exists between the R/S polymorphism and expression of integrin αV-β3, and/ or the antiviral activity in the supernatants of those cultures. Our data show that different R/S patterns to FMDV in vitro. Between 2% and 85% of the fibroblasts in the PCF-BON samples expressed integrin aV-b3. Interestingly, a correlation between R/S and expression of this receptor was obs.. Read More»
  DOI: 10.4172/2157-7579.1000219

  Abstract PDF