Journal of AIDS & Clinical Research

Marianna K Baum

Publications

• Research Article
  Effect of GSTM1-Polymorphism on Disease Progression and Oxidative Stress in HIV Infection: Modulation by HIV/HCV Co-Infection and Alcohol Consumption
  Author(s): Mary Parsons, Adriana Campa, Shenghan Lai, Yinghui Li, Janet Diaz Martinez, Jorge Murillo, Pedro Greer, Sabrina Sales Martinez and Marianna K BaumMary Parsons, Adriana Campa, Shenghan Lai, Yinghui Li, Janet Diaz Martinez, Jorge Murillo, Pedro Greer, Sabrina Sales Martinez and Marianna K Baum
  
  Objective: To examine the effects of GSTM1 null-allele polymorphism on oxidative stress and disease progression in HIV infected and HIV/hepatitis C (HCV) co-infected adults. Methods: HIV-infected and HIV/HCV co-infected participants aged 40-60 years old with CD4 cell count >350 cells/ μl, were recruited. GSTM1 genotype was determined by quantitative PCR. Oxidative stress (mitochondrial 8-oxo-2’- deoxyguanosine [8-oxo-dG], malondialdehyde [MDA], oxidized glutathione and Complexes I and IV), apoptosis and HIV disease (CD4 count and viral load) markers were measured. Gene copies were not quantified, thus the Hardy- Weinberg formula was not applicable. Results: Of the 129 HIV-infected participants, 58 were HIV/HCV co-infected. GSTM1 occurred in 66% (62/94) in those of African descent, and 33% (11/33) of the Caucasians. Those with GSTM1 coding for the functional.. Read More»
  DOI: 10.4172/2155-6113.1000237

  Abstract PDF