Molecular and Genetic Medicine

Marie-Claude Vohl

Publications

• Research Article
  Use of Blood as a Surrogate Model for the Assessment of Visceral Adipose Tissue Methylation Profiles Associated with the Metabolic Syndrome in Men
  Author(s): Frédéric Guénard, Yves Deshaies, Frédéric-Simon Hould, Stéfane Lebel, André Tchernof, Picard Marceau and Marie-Claude VohlFrédéric Guénard, Yves Deshaies, Frédéric-Simon Hould, Stéfane Lebel, André Tchernof, Picard Marceau and Marie-Claude Vohl
  
  Epigenetic mechanisms are known to be involved in tissue-specific differentiation. DNA methylation patterns have been shown to be largely conserved across tissues but with variation for specific genes. However, it is unclear whether the variability observed in the methylation profile of a metabolically active tissue is reflected in other sources such as hematopoietic tissue. This study aimed to test blood genome-wide CpG site methylation levels as a surrogate model for visceral adipose tissue (VAT) methylation and to verify whether it appropriately reflects differences in methylation levels found in VAT between men discordant for the metabolic syndrome (MetS). Tissue specimens (VAT and blood samples) were obtained from 16 severely obese individuals discordant for the MetS. CpG sites methylation levels were measured with the Infinium HumanMethylation450 BeadChip and correlations of met.. Read More»
  

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