Journal of Diabetic Complications & Medicine

Marija Šantl Letonja

Publications

• Research Article
  Polymorphisms rs1800587 and rs1143634 of the Interleukin-1α Gene are associated with the Progression of Carotid Atherosclerosis in Caucasians with Type 2 Diabetes Mellitus
  Author(s): Aleš Pleskovič, Jovana Nikolajević Starcević, Sara Mankoč, Ines Cilenšek, Marija Šantl Letonja, Jana Makuc, Andreja Cokan Vujkovac and Daniel PetrovičAleš Pleskovič, Jovana Nikolajević Starcević, Sara Mankoč, Ines Cilenšek, Marija Šantl Letonja, Jana Makuc, Andreja Cokan Vujkovac and Daniel Petrovič
  
  Background: Our study was designed to test the possible association between either polymorphisms T889C (rs1800587) or C3954T (rs1143634) of the interleukin-1 alpha (IL-1α) gene with subclinical markers of carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM). Moreover, the effect of both polymorphisms on progression of carotid atherosclerosis in 3.8-year follow-up was studied. Patients and methods: 595 subjects with T2DM were enrolled in the prospective study. Subclinical markers of carotid atherosclerosis were assessed with ultrasound at the time of recruitment and after 3.8-years. Genotyping of two polymorphisms (rs1800587, rs1143634) was performed with real-time PCR System. Results: The comparison of atherosclerosis parameters was performed with regard to different genotypes of IL-1α rs1800587 and rs1143634 polymorphisms upon enrolment. Multiple lin.. Read More»
  DOI: 10.4172/2475-3211.1000113

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