Cardiovascular Diseases & Diagnosis

Mario Lescan

Publications

• Research Article
  Beneficial Effects On Cardiac Performance and Cardioprotective Properties of Milrinone after Cold Ischemia
  Author(s): Mario Lescan, Albertus Scheule, Bernd Neumann, Christoph Haller, Julia Westendorff, Hans Peter Wendel, Gerhard Ziemer, Christian Schlensak and Tobias WalkerMario Lescan, Albertus Scheule, Bernd Neumann, Christoph Haller, Julia Westendorff, Hans Peter Wendel, Gerhard Ziemer, Christian Schlensak and Tobias Walker
  
  Background: Cold Ischemia-Reperfusion Injury (CIRI) is regarded as the major cause of early graft dysfunction after cardiac transplantations and is associated with rejection episodes. Consequently, it is one of the main therapeutic targets in order to improve survival after heart transplantation. The aim of this study was to evaluate hemodynamic effects of milrinone and its influence on the markers of myocardial damage when used in a piglet working heart model with a cold ischemia-reperfusion setting. Methods: Hearts of 18 piglets were examined in a homologous blood-perfused, working heart model to get baseline measurements. After hypothermic cardioplegic arrest and storage on ice for 60 minutes, the hearts received either milrinone or served as controls. All hearts were examined for 45 minutes in the working heart model. Hemodynamic paramet.. Read More»
  DOI: 10.4172/2329-9517.1000124

  Abstract PDF