Journal of Bioengineering & Biomedical Science

Mark D Smith MD

Publications

• Research Article
  In Vitro Effects of Extracorporeal Shockwave Therapy (ESWT) on Proliferation and Metabolic Activity of Adult Human Keratinocytes
  Author(s): Christian Ottomann MD, Vlado Antonic, Sandra Münch, Claudia Belfekroun, Gerald Niedobitek MD, Beate Petschke, Mark D Smith MD, Richard Thiele MD, Wolfgang Schaden MD and Bernd Hartmann MDChristian Ottomann MD, Vlado Antonic, Sandra Münch, Claudia Belfekroun, Gerald Niedobitek MD, Beate Petschke, Mark D Smith MD, Richard Thiele MD, Wolfgang Schaden MD and Bernd Hartmann MD
  
  Background: The objective of the presented study is to investigate in vitro effects of low energy extracorporeal shockwave therapy (ESWT) on the keratinocytes and their metabolic and proliferative properties for their therapeutic applications. Materials: Primary culture of keratinocytes was isolated from clinical samples and after passaging into 12 flasks exposed to the various number of ESWT impulses (n=25, 50 and100impulses) in combination with several frequencies (1, 3 or 5Hz) and distances from the applicator head (5, 6 or 7cm with corresponding energy flux densities (EFD)=0.04, 0.025 and 0.015 mJ/mm2, respectively) using modified water bath at constant temperature 37°C. Flasks were assigned to receive one combination of treatment parameters. The individually tested distances/EFD with the various impulse numbers an.. Read More»
  DOI: 10.4172/2155-9538.1000171

  Abstract PDF