Vitamins & Minerals

Mark Speechley

Publications

• Research Article
  Proton Pump Inhibitors and Lower Serum Ferritin Levels in 171 HFE C282Y Homozygotes in the Hemochromatosis and Iron Overload Screening Study
  Author(s): James C Barton, Paul C Adams, Ronald T Acton, Mark Speechley, Christine E McLaren, Gordon D McLaren, Victor R Gordeuk and John H EckfeldtJames C Barton, Paul C Adams, Ronald T Acton, Mark Speechley, Christine E McLaren, Gordon D McLaren, Victor R Gordeuk and John H Eckfeldt
  
  In non-screening hemochromatosis patients with HFE C282Y homozygosity who achieve iron depletion, the proton pump inhibitor (PPI) omeprazole decreases non-heme iron absorption from test meals and decreases maintenance phlebotomy requirements. We sought to determine the effect of taking PPIs and histamine H2 receptor antagonists (H2RAs) on serum ferritin (SF) levels in C282Y homozygotes diagnosed in a screening study. Methods: We compared mean ln SF in 171 homozygotes (60 men, 111 women) who reported taking and not taking PPIs and H2RAs. We performed linear regression on ln post-screening SF using age, sex, reports of taking PPIs and H2RAs, and free thyroxine levels. Results: Eleven homozygotes (6.4%) took PPIs; twelve (6.7%) took H2RAs. Mean ln SF values of male and female homozygotes who took PPIs were ~one-half those of homozygotes without PPI reports, but the differences were not s.. Read More»
  DOI: 10.4172/vms.1000112

  Abstract PDF