Journal of AIDS & Clinical Research

Martha S

Publications

• Review Article
  The Relative Balance between Th17 and Regulatory T cell subsets is Critical for Progression of HIV Infection
  Author(s): Maina EK, Bukusi EA, Martha S, Lartey M and Ampofo WKMaina EK, Bukusi EA, Martha S, Lartey M and Ampofo WK
  
  HIV pathogenesis is extremely complex and involves both immunodeficiency that leads to opportunistic infections and AIDS as well as excessive inflammation and systemic immune activation. Generalized chronic immune activation and the progressive loss of the balance between T-helper 17 (Th17) and T-regulatory (Treg) cells have been demonstrated as leading events in HIV pathogenesis. Recent studies have investigated interactions between Th17 and Treg cells in relation to HIV infection. Th17 cells are perturbed during HIV infection in humans and SIV infection in nonhuman primates. Studies of Th17 cells in humans and nonhuman primates has shown that depletion of these cells is associated with the dissemination of microbial products from the infected gut, increased systemic immune activation, and disease progression. Treg cells, another small sub-population of T-cells involved in preventing.. Read More»
  DOI: 10.4172/2155-6113.1000395

  Abstract PDF