Transplantation Technologies & Research

Martin Roy First

Publications

• Research Article
  Clinical Utility of Peripheral Blood Gene Expression Profiling of Kidney Transplant Recipients to Assess the Need for Surveillance Biopsies in Subjects with Stable Renal Function
  Author(s): Martin Roy First, Thomas Whisenant, John J Friedewald, Peter Lewis, Stan Rose, Darren Lee, Deirdre Pierry, Sunil M Kurian, Terri Gelbart and Michael M AbecassisMartin Roy First, Thomas Whisenant, John J Friedewald, Peter Lewis, Stan Rose, Darren Lee, Deirdre Pierry, Sunil M Kurian, Terri Gelbart and Michael M Abecassis
  
  Background: TruGraf is a blood test that measures gene expression signatures in kidney transplant recipients, providing information on adequacy of immunosuppression. Signatures derived from peripheral blood using DNA microarrays have been internally and externally validated in two populations of transplant recipients: (i) patients designated as TX (“Transplant eXcellence”) - stable serum creatinine and normal biopsy, indicative of immune quiescence, and (ii) patients designated as not-TX (renal dysfunction and/or histological abnormalities). The test is intended for use in subjects with stable renal function as an alternative to protocol biopsies. Methodology: Simultaneous blood tests and transplant biopsies were performed in 169 patients. The molecular laboratory was blinded to renal function and biopsy results. Result.. Read More»
  DOI: 10.4172/2161-0991.1000177

  Abstract PDF