Journal of Nephrology & Therapeutics

Marzog Saeed AL Nasser

Publications

• Research Article
  Therapeutic Drug Monitoring of Tacrolimus in Saudi Kidney Transplant Patients
  Author(s): Marzog Saeed AL Nasser, Ahmed S Ali, Mai A Abdul Sattar, Ezz H Abdulfattah, Lateef M Khan and Khalid Abdullah Al-AlsheikhMarzog Saeed AL Nasser, Ahmed S Ali, Mai A Abdul Sattar, Ezz H Abdulfattah, Lateef M Khan and Khalid Abdullah Al-Alsheikh
  
  Background: Tacrolimus is immunosuppressive agent used for the prevention of rejection in kidney transplant patients, has narrow therapeutic range, and variable pharmacokinetics. Objectives: To identify the optimum Tacrolimus blood trough level for Saudi kidney transplant patients (SKTP). Method: The research population consisted of 100 SKTP at the Armed Forces Hospital in the Southern Region (AFHSR) treated with Tacrolimus and followed-up for a period of 24 months (2012 till 2014). Results: A significant relationship between Tacrolimus trough level and incidence of kidney rejection was remarkably found only after 180 days post-transplantation. During this period, Tacrolimus mean trough level (ng/ml) was 7.4 ± 0.2 in SKTP with no rejection, 5.3 ± 0.7 for those with acute rejection, and 3.8 ± 0.4 for those with chronic rejection. Furthermore, the coefficient of var.. Read More»
  DOI: 10.4172/2161-0959.1000264

  Abstract PDF