International Journal of Neurorehabilitation

Masahiro Yokoo

Publications

• Research Article
  Neuronal Plasticity in the Developing and Aging Cerebral Cortices of Patients with Down Syndrome
  Author(s): Miwa Takashima, Seiichiro Takahashi, Osuke Iwata, Sachiko Iwata, Masahiro Yokoo and Sachio TakashimaMiwa Takashima, Seiichiro Takahashi, Osuke Iwata, Sachiko Iwata, Masahiro Yokoo and Sachio Takashima
  
  Background: The aim of the study was to clarify the developmental and aging changes of Protein gene product 9.5 (PGP9.5) expression in granular and pyramidal neurons of the cerebral cortex comparing patients with Down syndrome (DS) and subjects without it. Subjects and Methods: Fifty-four human brains were obtained from post-mortem samples of 24 subjects with DS (19 weeks gestation (GW) to 63 years of age) and 30 subjects without it (20 GW to 75 years of age). PGP9.5 expression in the frontal cerebri was qualitatively assessed in specific cortical layers and compared among 4 age groups (fetus, infant, child, and adult), and between the brains with and without DS. Results: In subjects without DS, the expression of PGP9.5 in the cerebral cortex was highest from 30 to 39 GW, and then decreased with increasing age. In .. Read More»
  DOI: 10.4172/2376-0281.1000111

  Abstract PDF