Neurological Disorders

Masayuki Shimono

Publications

• Research Article
  Successful, Short-Term Drug Exchange Protocol in Epilepsy: Transient Addon of Intravenous Anti-Epileptic Drugs
  Author(s): Tomofumi Fukuda, Masayuki Shimono, Masahiro Ishii, Ayako Senju, Yumeko Matsuda, Shiho Takano, Naoki Shiota and Koichi KusuharaTomofumi Fukuda, Masayuki Shimono, Masahiro Ishii, Ayako Senju, Yumeko Matsuda, Shiho Takano, Naoki Shiota and Koichi Kusuhara
  
  Newer antiepileptic drugs (AEDs) are supposed to be more beneficial at controlling seizures than older AEDs. We substituted newer AEDs for older AEDs while conducting a transient add-on of an intravenous (IV) antiepileptic drug (AED) as a base therapy (AED adjustment), and in the present paper we evaluate the efficacy and safety of this method. The study participants were 40 consecutive referral patients with intractable epilepsy who had been treated with two or more AEDs but had epileptic seizure which spoiled their quality of life. Five of the patients were excluded because any IV AEDs exacerbated their clinical seizures and electro-encephalography (EEG). The mean age of the remaining 35 patients was 7.5 (range: 1.2 - 20.5). The patients had been on two to five AEDs (mean 3.3), and experienced seizures ranging from 0.2 to 100 times/day (mean 13.0). We kept the patients on one or two.. Read More»
  DOI: 10.4172/2329-6895.1000349

  Abstract PDF