Journal of Computer Science & Systems Biology

Massimo Mezzavilla

Publications

• Research Article
  Neon: An R Package to Estimate Human Effective Population Size and Divergence Time from Patterns of Linkage Disequilibrium between SNPS
  Author(s): Massimo Mezzavilla and Silvia GhirottoMassimo Mezzavilla and Silvia Ghirotto
  
  Objective: Estimating the effective population size (Ne) is crucial to understanding how populations evolved, expanded or shrunk. One possible approach is to compare DNA diversity, so as to obtain an average Ne over many past generations; however as the population sizes change over time, another possibility is to describe this change. Linkage Disequilibrium (LD) patterns contain information about these changes, and, whenever a large number of densely linked markers are available, can be used to monitor fluctuating population size through time. Here, we present a new R package, NeON that has been designed to explore population’s LD patterns to reconstruct two key parameters of human evolution: the effective population size and the divergence time between populations. Methods: NeON starts with binary or pairwise-LD PLINK.. Read More»
  DOI: 10.4172/jcsb.1000168

  Abstract PDF