Cancer Science & Therapy

Matias Pebet

Publications

• Research Article
  Genes Encoding Enzymatic Activities Implicated in the Eicosanoid Cascade of Arachidonic Acid and their Receptors are Expressed at mRNA Levels in Human Meningiomas
  Author(s): Rafael De Armas, Karine Durand, Nicolas Weinbreck, Sandrine Robert, Jean-Jacques Moreau, Matias Pebet, François Labrousse and Yves DenizotRafael De Armas, Karine Durand, Nicolas Weinbreck, Sandrine Robert, Jean-Jacques Moreau, Matias Pebet, François Labrousse and Yves Denizot
  
  In view of the important oncogenic action of lipoxygenase (LOX) and cycloxygenase (COX) enzymatic activities we investigated, by using real time PCR, their presence in human meningiomas. Results indicated the presence of 5-LOX, 12-LOX, 15-LOX1, 15-LOX2, COX-1, COX-2, prostaglandin E (PGE) synthase, prostacyclin (PGI) synthase and thromboxane (TX) synthase transcripts in meningiomas but without relation to the tumor grade, the subtype of meningiomas, the presence of inflammatory infiltrated cells, of an associated edema, mitosis, brain invasion, vascularisation or necrosis. Similar results were found for BLT1 and BLT2 transcripts (encoding LTB4 receptors) and for prostanoid receptor transcripts (EP1-4 for PGE2, IP for PGI2 and TP for TXA2). In conclusion, genes encoding enzymatic activities implicated in the eicosanoid cascade are expressed in meningiomas. LOX- and COX-derived arachido.. Read More»
  DOI: 10.4172/1948-5956.1000015

  Abstract PDF