Molecular Biomarkers & Diagnosis

Matteo Biasotto

Publications

• Research Article
  The Effect of Amino-Bisphosphonate Therapy on Gingival Crevicular Fluid Alkaline Phosphatase Activity in Cancer Patients
  Author(s): Katia Rupel, Giuseppe Perinetti, Luca Contardo, Giulia Ottaviani, Margherita Gobbo, Sara De Iudicibus, Roberto Di Lenarda and Matteo BiasottoKatia Rupel, Giuseppe Perinetti, Luca Contardo, Giulia Ottaviani, Margherita Gobbo, Sara De Iudicibus, Roberto Di Lenarda and Matteo Biasotto
  
  The enzyme Alkaline Phosphatase (ALP) is considered a biomarker of bone formation and it is used for monitoring intravenous Bisphosphonate (BP) therapy. It can be measured in serum and urine, but also in Gingival Crevicular Fluid (GCF). The aim of the present study was to monitor the GCF-ALP activity fluctuations in cancer patients before and during the first six months of BP therapy, comparing them with systemic serum ALP concentrations. 33 patients and 25 controls were enrolled according to the eligibility criteria. The GCF was collected at baseline, and after every BP administration for 6 times. The total ALP activities were determined spectrophotometrically. The results show how the differences in GCF-ALP activity over time appear to be significant in the BP-taking group (p=0.003), while the differences in serum ALP in the BP-taking group and in GCF-ALP activity in the control gro.. Read More»
  DOI: 10.4172/2155-9929.1000166

  Abstract PDF