Transplantation Technologies & Research

Maureen Shuh

Publications

• Research Article
  Tissue Inhibitor of Metalloproteinase-3 Ameliorates Total Sublethal Hepatic Ischemia/Reperfusion Injury in a Rat Model
  Author(s): Maureen Shuh, O. Rama Swamy, Christopher P. Zetzmann, George E. Loss, Humberto Bohorquez and Ari J. CohenMaureen Shuh, O. Rama Swamy, Christopher P. Zetzmann, George E. Loss, Humberto Bohorquez and Ari J. Cohen
  
  Orthotopic liver transplantation is the only treatment for end stage liver disease. Recipients outweigh the number of available healthy donor livers, and options for increasing the donor pool have included the use of marginal livers. Transplantation of marginal livers is a known risk factor for the development of primary non-function post-transplant. Although the precise cause of primary non-function is not known, ischemia/reperfusion (I/R) injury has been strongly implicated, and tumor necrosis factor-α (TNF-α) plays a critical role. We utilized a rat I/R model to determine whether treatment with tissue inhibitor of metalloproteinase-3 (TIMP-3) after total sublethal I/R injury improves liver health by preventing the release of active TNF-α. Rats were pre-treated with either TIMP-3 or saline and underwent total warm hepatic ischemia followed by 6, 24, 48 hours or 7 d.. Read More»
  DOI: 10.4172/2161-0991.S3-003

  Abstract PDF