Journal of Bioanalysis & Biomedicine

Md. Didaruzzaman Sohel

Publications

• Research Article
  Study of Interaction between Febuxostat and Bovine Serum Albumin by Fluorescence Spectroscopy
  Author(s): Sikder Nahidul Islam Rabbi, Md. Zamil Sultan, Md. Didaruzzaman Sohel and Md. Zakir SultanSikder Nahidul Islam Rabbi, Md. Zamil Sultan, Md. Didaruzzaman Sohel and Md. Zakir Sultan
  
  The interaction of an anti-gout drug, febuxostat was studied with bovine serum albumin (BSA) applying fluorescence quenching method for the first time. Interaction parameter and magnitude of the force indicated for both, dynamic and static quenching in between febuxostat and BSA protein. Thermodynamic studies indicated for both hydrogen and hydrophobic interactions, observed at 280 nm and only hydrophobic at 293 nm excitation wavelength. Negative ΔHo and positive ΔSo, indicated for distinctive characteristics for the existence of both, hydrogen and hydrophobic binding throughout the interactions. The binding constant Kb at λex=280 nm was 3.467 × 103 μM-1 and 4.943 × 103 μM-1 at 298 and 308 K temperature whereas, 5.54 × 103 μM-1 and 4.44 ×.. Read More»
  DOI: 10.4172/1948-593X.1000138

  Abstract PDF