Transplantation Technologies & Research

Mehmet Uzunel

Publications

• Research Article
  Decreased Risk of Acute Graft-versus-Host Disease Using Reduced Intensity Conditioning Compared to Myeloablative Conditioning is Independent of Donor-Recipient T-cell Chimerism
  Author(s): Olle Ringdén, Mehmet Uzunel, Behnam Sadeghi, Martin Solders, Michael Uhlin, Jonas Mattsson and Mats RembergerOlle Ringdén, Mehmet Uzunel, Behnam Sadeghi, Martin Solders, Michael Uhlin, Jonas Mattsson and Mats Remberger
  
  Background: It is not known if the reduced risk of graft-versus-host disease (GVHD) among patients receiving reduced intensity conditioning (RIC) as opposed to myeloablative conditioning (MAC) is due to differences in mixed donor-recipients chimerism, or to the intensity of the regimen. Methods: We compared patients with acute myeloid leukemia (AML) selected for RIC (n=47) to 46 patients selected for MAC before allogeneic hematopoietic stem cell transplantation (HSCT). Results: Time to neutrophils >0.5 x 109/L was median 15 days in the MAC group, which was faster than 17 days in the RIC group (p=0.001). MAC patients required more erythrocytes (p=0.001) and platelet transfusions (p=0.003). At four weeks, mixed donor-recipient T-cell chimerism was seen in 29% of the MAC patients and 46% of the RIC patients.. Read More»
  DOI: 10.4172/2161-0991.1000142

  Abstract PDF