Cancer Science & Therapy

Mendez-Ramirez I

Publications

• Research Article
  Free and DNA Adducted Aflatoxins in Chronic Liver Diseases that Predispose Patients to Hepatocellular Carcinoma in Mexico
  Author(s): Alvarez-Banuelos MT, Carvajal-Moreno M, Mendez-Ramirez I and Rojo-Callejas FAlvarez-Banuelos MT, Carvajal-Moreno M, Mendez-Ramirez I and Rojo-Callejas F
  
  Aflatoxins are mutagenic hepatocarcinogenic fungal metabolites that contribute to chronic hepatitis B and C and viral cirrhosis, which can both evolve into hepatocellular carcinoma. Objective: To identify and quantify free aflatoxins and AFB1-N7-guanine (AFB1-N7-Gua) adducts (active carcinogen) in the urine of Mexican patients with chronic liver diseases. Methods: Urine samples from 210 Mexican patients with chronic liver diseases, hepatitis B or C, or viral cirrhosis and four control groups: 1) patients with alcoholic cirrhosis, 2) patients with no hepatic diseases, 3) patients with kidney failure, and 4) healthy persons, were analyzed for free aflatoxins and AFB1-N7-Gua adducts by Inhibitory Indirect ELISA and high performance liquid chromatography, and both methods produced similar results (R2=0.90). A questionnaire regarding foods .. Read More»
  DOI: 10.4172/1948-5956.1000363

  Abstract PDF