Cardiovascular Diseases & Diagnosis

Messias Antônio Araújo

Publications

• Research Article
  A New Investigative Approach: How the Angiotensin-Converting Enzyme Gene Interacts with Coronary Risk Factors
  Author(s): Messias Antônio Araújo, Morun Bernardino-Neto, Denis Souza, Augusto Coelho Rocha, Ralf Pereira JR, Caio Siqueira Vasconcelos, Camila Leles Nascimento, Ariane Malta Pereira, Ana Leticia Vieira Castro and Elisangela Rosa CordeiroMessias Antônio Araújo, Morun Bernardino-Neto, Denis Souza, Augusto Coelho Rocha, Ralf Pereira JR, Caio Siqueira Vasconcelos, Camila Leles Nascimento, Ariane Malta Pereira, Ana Leticia Vieira Castro and Elisangela Rosa Cordeiro
  
  How each Angiotensin-Converting Enzyme (ACE) genotype modulates the magnitude of the effect of each coronary risk factor. Background: Coronary Artery Disease (CAD) is based on atherosclerosis, which is a multifactorial-multigenic disease. This study investigated when interacting with them in the genesis of this pathology. Methods: The study included 630 subjects, including one group with 396 CAD-confirmed patients and another with 234 controls without angiographic lesions. Classical risk factors of CAD and ACE gene polymorphisms were evaluated using nested PCR. The association between the DD, ID and II genotypes with classical risk factors was analysed statistically by comparing the patient and control groups using the binomial frequency comparison test and the power test. Results: Of the 630 individuals,.. Read More»
  DOI: 10.4172/2329-9517.1000296

  Abstract PDF