Journal of Blood & Lymph

Micaela Morais

Publications

• Research Article
  Non-Hodgkin Lymphoma’s Therapy by CAR-T Cells
  Author(s): Micaela Morais, Fernando José Figueiredo Agostinho D’Abreu Mendes and Rui CruzMicaela Morais, Fernando José Figueiredo Agostinho D’Abreu Mendes and Rui Cruz
  
  Lymphoma is a type of cancer that causes the proliferation of B or T cells in lymph nodes. Lymphomas can be characterized in Hodgkin Lymphoma (HL) and Non-Hodgkin Lymphoma (NHL), which account for about 85% of lymphoma diagnoses. The Immune System (IS) has the innate ability to identify and eliminate cells with tumor potential. Despite this, our body sometimes can’t combat this type of pathologies alone due to the mechanisms of tumor escape. T cells, which are very important cells in antitumor activity, have been studied and some trials show that the use of CAR-T cells may present an added value for the treatment of this type of pathologies. The CAR-T cells are genetically modified T lymphocytes to express the specific antibody binding site, directing autologus polyclonal T cells to bind to a specific Tumor Associated Antigen (TAA). The design and structure of CAR-T are determin.. Read More»
  DOI: 10.4172/2165-7831.1000175

  Abstract PDF