Molecular Biomarkers & Diagnosis

Michael D Weiden

Publications

• Research Article
  YKL-40 is a Protective Biomarker for Fatty Liver in World Trade Center Particulate Matter-Exposed Firefighters
  Author(s): Soo Jung Cho, Ghislaine C Echevarria, Young Im Lee, Sophia Kwon, Kwan Yong Park, Jun Tsukiji, William N Rom, David J Prezant, Anna Nolan and Michael D WeidenSoo Jung Cho, Ghislaine C Echevarria, Young Im Lee, Sophia Kwon, Kwan Yong Park, Jun Tsukiji, William N Rom, David J Prezant, Anna Nolan and Michael D Weiden
  
  Background: Serum biomarkers of metabolic syndrome predict abnormal lung function in World Trade Center particulate matter (WTC-PM)-exposed Fire Department of New York (FDNY) rescue workers. In animal models, exposure to ambient PM induces non-alcoholic fatty liver disease (NAFLD), a well-known comorbidity of metabolic syndrome. YKL-40 is an inflammatory biomarker for both liver and lung disease. We tested if YKL-40 is a biomarker for NAFLD in this dust-exposed cohort. Methods: Using a nested case-control design, we studied 131 FDNY personnel who had Computer Tomography performed within 5 years post 9/11. NAFLD was defined by a liver/spleen attenuation ratio of ≤1. Serum biomarkers, lipid panel and liver function were measured in serum that had been drawn within 6 months of September 11, 2001. YKL-40 and chitotriosidase were assayed by EL.. Read More»
  DOI: 10.4172/2155-9929.1000174

  Abstract PDF