Journal of AIDS & Clinical Research

Michael Sneller

Publications

• Research Article
  HIV-1 Treated Patients with Undetectable Viral Loads have Lower Levels of Innate Immune Responses via Cytosolic DNA Sensing Systems Compared with Healthy Uninfected Controls
  Author(s): Sanjay Swaminathan, Hongyan Sui, Joseph W Adelsberger, Qian Chen, Michael Sneller, Stephen A Migueles, Shyamasundaran Kottilil, Alexander Ober, Sara Jones, Catherine A Rehm, H Clifford Lane and Tomozumi ImamichiSanjay Swaminathan, Hongyan Sui, Joseph W Adelsberger, Qian Chen, Michael Sneller, Stephen A Migueles, Shyamasundaran Kottilil, Alexander Ober, Sara Jones, Catherine A Rehm, H Clifford Lane and Tomozumi Imamichi
  
  Objectives: After DNA or RNA virus infection, cytosolic foreign DNA or RNA derived from the infecting viruses is recognized by intracellular pathogen recognition receptors (PRRs) and induces activation of the innate immune system. Transfection of DNA has been used as an experimental model for DNA virus-mediated innate responses. We have previously reported that DNA transfection preferentially induces Type-III IFN (IFN-λ1) rather than Type-I IFN (IFN-β). In this study, we compared the DNA-mediated immune response between healthy controls and HIV-1 infected patients with undetectable viral loads and assessed potential innate immune responses in these patients. Methods: The study consisted of 50 HIV-1 negative healthy donors, 46 patients on combination antiretroviral therapy with HIV-1 viral loads <50 copies/ml and 7 long term non-progressors (LTNPs). PBMCs were is.. Read More»
  DOI: 10.4172/2155-6113.1000315

  Abstract PDF