Journal of Clinical Case Reports

Michele De Tursi

Publications

• Case Report
  Long Term Survival of a Patient with Metastatic Renal Cell Carcinoma Treated with Half-Dose Pazopanib: A Case Report
  Author(s): Giada Cortese, Maria Teresa Martino, Elisabetta Gambale, Clara Natoli and Michele De TursiGiada Cortese, Maria Teresa Martino, Elisabetta Gambale, Clara Natoli and Michele De Tursi
  
  We describe the case of a 59-year-old woman who underwent a radical left nephrectomy for renal cell cancer in 1993. After 7 years, the disease relapsed as thyroid and pulmonary metastases and she has been initially treated with chemotherapy. At further progression we administered an antiangiogenic drug, Sunitinib for 9 months then we switched to Pazopanib. The patient is still receiving a half-dose of Pazopanib (46 months) and she is showing a longlasting response with an optimal safety profile. In this patient, Pazopanib demonstrated a significant improvement in PFS and tumor response also with half a dose. Nephrectomy, metastasectomy, medical therapy and targeted treatments have been shown able to prolong survival and improve quality of life. This is an example of chronicized disease in a patient who can be defined as a long-term survivor. .. Read More»
  DOI: 10.4172/2165-7920.1000658

  Abstract PDF