Journal of Clinical Case Reports

Michele De Tursi

Publications

• Case Report
  Immunotherapy and Hypophysitis in the Clinical Practice: A Case Report
  Author(s): Elisabetta Gambale, Camilla Tinari, Consiglia Carella, Alessandra Di Paolo and Michele De TursiElisabetta Gambale, Camilla Tinari, Consiglia Carella, Alessandra Di Paolo and Michele De Tursi
  
  The reported frequency of ipilimumab-induced hypophysitis (IIH), a cytotoxic T-lymphocyte antigen 4 antibody, ranges from 0 to 17%, in contrast to the rarity of idiopathic autoimmune hypophysitis that has an estimated incidence of one in nine million people per year. Here we present the case of a patient with ipilimumab- induced hypophysitis (IIH). After his third course of ipilimumab, the patient began to present worsening asthenia and severe headache. A brain MRI scan showed the mild swelling of the anterior pituitary gland and thickening of the stalk. Haematological reports were consistent with hypophysitis diagnosis: in fact, ACTH and cortisol levels were very low. Then ipilimumab was interrupted and therapy with a large dose of glucocorticoids (dexamethasone) was promptly started. A rapid symptoms improvement was obtain.. Read More»
  DOI: 10.4172/2165-7920.1000861

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