Journal of AIDS & Clinical Research

Michelo C

Publications

• Research Article
  Renal Dysfunction among HIV-infected Patients on Tenofovir-Based Antiretroviral Therapy at Ronald Ross Hospital in Zambia
  Author(s): Wantakisha E, Chongwe G, Munkombwe D and Michelo CWantakisha E, Chongwe G, Munkombwe D and Michelo C
  
  Objective: Tenofovir Disoproxil Fumerate (TDF) is contraindicated for use in HIV infected patients when creatinine clearance (CrCl) is below 50ml/min. We determined prevalence and factors associated with renal dysfunction at 18 months follow up in adult HIV positive patients on TDF-based antiretroviral therapy (ART). Methods: We conducted a cross sectional study of 445 HIV positive patients’ records on a TDF-regimen at Ronald Ross General Hospital in Zambia. Patient’s records in data management software (SMARTCARE) from 2008 to 2014 were reviewed to determine proportions of patients on TDF developing renal dysfunction. We estimated glomerular filtration rate (GFR) by creatinine clearance using the Cockcroft-Gault formula to determine renal dysfunction. CrCl level ≤ 50 ml/min indicated renal dysfunction. Multiple logistic regression was used to determine factors associa.. Read More»
  DOI: 10.4172/2155-6113.1000651

  Abstract PDF