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Case Report
Voriconazole-Associated Periostitis in a Heart Transplant Patient
Author(s): Miguel Hernandez PampaloniMiguel Hernandez Pampaloni
A 60 year-old female with a history of a heart transplant was treated with voriconazole for presumed pulmonary aspergillosis. After approximately three months, she began to experience progressively worsening musculoskeletal pain. Her presentation was notable for widespread tenderness, a lack of digital clubbing, and elevated alkaline phosphatase. Bone scintigraphy demonstrated increased activity at multiple locations correlating with the patient’s pain. Periostitis was identified in these locations on radiographs. A few months after discontinuing voriconazole, the patient’s pain had resolved, alkaline phosphatase had normalized, and abnormal activity on scintigraphy had markedly improved.
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DOI:
10.4172/2165-7920.1000166
Journal of Clinical Case Reports received 1345 citations as per Google Scholar report