Medicinal Chemistry

Mikio Nishizawa

Publications

• Research Article
  Japanese Herbal Medicine Hochuekkito Inhibits the Expression of Proinflammatory Biomarker, Inducible Nitric Oxide Synthase, in Hepatocytes
  Author(s): Miho Matsumiya, Masaki Kaibori, Yoshiro Araki, Takashi Matsuura, Masaharu Oishi, Yoshito Tanaka, Mikio Nishizawa, Tadayoshi Okumura and A-Hon KwonMiho Matsumiya, Masaki Kaibori, Yoshiro Araki, Takashi Matsuura, Masaharu Oishi, Yoshito Tanaka, Mikio Nishizawa, Tadayoshi Okumura and A-Hon Kwon
  
  Hochuekkito (TJ-41) is used for the treatment of complaints in patients with general fatigue. However, there is little scientific evidence to demonstrate the liver-protective effects of TJ-41. In the inflamed liver, proinflammatory cytokines stimulate the induction of inducible nitric oxide synthase (iNOS). Over-production of NO by iNOS has been implicated as a factor in liver injury. We examined proinflammatory cytokine-stimulated hepatocytes as a simple in vitro injury model to determine liver-protective effects of TJ-41. The objective was to investigate whether TJ-41 influences iNOS induction and to determine its mechanism. Primary cultured rat hepatocytes were treated with interleukin (IL)-1β in the presence or absence of TJ-41. The induction of iNOS and its signaling pathway were analyzed. IL-1β produced increased levels of NO. This effect w.. Read More»
  DOI: 10.4172/2161-0444.1000112

  Abstract PDF