Transplantation Technologies & Research

Milena Iwaszko

Publications

• Review Article
  Non-Classical MHC Class Ib Molecules and their Receptors–Role in Allogeneic Transplantation of Hematopoietic Stem Cells
  Author(s): Milena Iwaszko, Katarzyna Gebura and Katarzyna Bogunia-KubikMilena Iwaszko, Katarzyna Gebura and Katarzyna Bogunia-Kubik
  
  HLA-E, HLA-G, and major histocompatibility complex class I-related chain A and B (MICA and MICB) proteins belong to human non-classical Major Histocompatibility Complex (MHC) class Ib molecules. These molecules are well known as powerful modulators of the immune response. The majority of the mentioned proteins interact exclusively with receptors from the CD94/NKG2 c-type lectin family. The peptide-presenting HLA-E molecule is recognized by the NKG2A or NKG2C receptor, triggering a signal cascade leading to inhibition or activation of immune cell activity, respectively. Another member of this family is the NKG2D receptor that interacts with the MICA/B proteins, transducing signals that result in activation of immune cells. This article discusses the current knowledge in regard to the genetic properties and physiological functions of the molecules HLA-E and MICA/B as well as t.. Read More»
  DOI: 10.4172/2161-0991.1000117

  Abstract PDF