Pulmonary & Respiratory Medicine

Miller Sam

Publications

• Research Article
  Evidence of Elevated CXCR2 Agonists in Stable Outpatients with Cystic Fibrosis Compared with Healthy Controls
  Author(s): Lipson David A, Holsclaw Douglas, Imbesi Giovanna, Ferrin Marianne, Sims Michael, Miller Sam, Tal-Singer Ruth and Hadjiliadis DenisLipson David A, Holsclaw Douglas, Imbesi Giovanna, Ferrin Marianne, Sims Michael, Miller Sam, Tal-Singer Ruth and Hadjiliadis Denis
  
  Introduction: Recruitment and activation of inflammatory cells contributes to the pathophysiology of Cystic Fibrosis (CF). Recruitment is initiated, in part, by engagement of the CXCR2 receptor on neutrophils and other inflammatory cells. Materials and Methods: Levels of CXCR2 agonists (CXCL 1, 3, 5, 7, 8), and systemic biomarkers of inflammation (fibrinogen, CC-16, SP-D, IL-1β, and MMP-9) were measured in the serum of stable outpatients with cystic fibrosis compared to normal healthy age-, gender, and racially-matched non-smoking control subjects. Secondary objectives included characterization of pulmonary function assessed by spirometry, Impulse Oscillometry (IOS), R5-R15 peripheral resistance, R5 total resistance and R25 large airway resistance; frequency dependent reactance as indicators of reactive.. Read More»
  DOI: 10.4172/2161-105X.1000149

  Abstract PDF