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Research Article
Effect of Exercise Training on Endogenous Stem Cells Activation in Ischemia Reperfusion Induced Skeletal Muscle Injury: A Physio- Histological Study
Author(s): Mira Farouk Youssef, Maha Baligh Zickri, Maha Gamal, Nadia Yassin, Lobna Abd ElAl and Noha ElhadaryMira Farouk Youssef, Maha Baligh Zickri, Maha Gamal, Nadia Yassin, Lobna Abd ElAl and Noha Elhadary
Background: This study aimed at investigating the possible role of exercise training in activating the migration of CD34 positive progenitor cells in a rat model of induced ischemia reperfusion injury (IRI) of limb skeletal muscle and related regeneration potential.
Material and methods: 28 adult male albino rats were divided into three groups: group I: control group; group II: IRI with 2 hours ischemia and 2 hours reperfusion, followed by immediate sacrifice (subgroup IIa) or delayed sacrifice after two weeks (subgroup IIb); group III: exercise in the form of group and gradual swimming for 4 weeks, followed by IRI and immediate sacrifice (subgroup IIIa), or delayed sacrifice (subgroup IIIb). Muscle performance was evaluated by physiological tests. Histological study was done using H&E staining, and immunohistochemical staining using anti .. Read More»
DOI:
10.4172/2157-7099.1000339
Journal of Cytology & Histology received 2334 citations as per Google Scholar report