Medicinal Chemistry

Mirabel C Ugwu

Publications

• Research Article
  Synthesis of Multi-Target Benzene-Sulphonamide Derivatives for the Treatment of Trypanosomiasis
  Author(s): David I Ugwu, Florence U Eze, Blessing C Ogboo, Victor N Okoro, Mirabel C Ugwu, Sunday N Okafor, Jude I Ayogu and Solomon I AttahDavid I Ugwu, Florence U Eze, Blessing C Ogboo, Victor N Okoro, Mirabel C Ugwu, Sunday N Okafor, Jude I Ayogu and Solomon I Attah
  
  Some derivatives of benzene-sulphonamides were synthesized via condensation reaction. Pharmacokinetic parameters were evaluated to assess the oral bioavailability, permeability and transport properties of the compounds. Molecular docking studies were performed on farnesyl diphosphate synthase, pteridine reductase, ornithine decarboxylase and rhodesain to assess the potential of the reported compounds in treating human African trypanosomiasis. All the compounds showed good binding to the target proteins assayed... Read More»
  

  Abstract PDF