Journal of Health & Medical Informatics

Mishra S

Publications

• Research Article
  Computational Comparative Homology Based 3D-structure Modelling of the HSp70 Protein from GWD
  Author(s): Mishra S and Gomase VSMishra S and Gomase VS
  
  Heat shock protein participates in several broad ranges of protein folding processes and control activity of regulatory proteins. Nearly all cells react in a similar manner against the external environmental abrupt changes like heat, chemicals such as analogues of amino acid, ethanol, arsenite, several heavy metals, mitochondrial functional inhibitors, cold, UV light. These all causes several severe, rapid changes in at the level of gene expression. The major significant activity of HSP protein to stabilize newly synthesized protein by securing its right folding, which generally undergone any damaged under cell stress condition. Through overexpression, this protein provides protection to cells against apoptotic cell death. The hsp70 chaperonis targeted as novel anticancer therapeutic candidate for a broad spectrum of tumor types due to its diverse functional role. Hom.. Read More»
  DOI: 10.4172/2157-7420.1000233

  Abstract PDF