Journal of Bioprocessing & Biotechniques

Moa Fransson

Publications

• Research Article
  Electrospinning; PLGA; Chitosan; Synthetic-natural scaffold; Mesenchymal stromal cells; Viability; Proliferation
  Author(s): Fatemeh Ajalloueian, Moa Fransson, Hossein Tavanai, Mohammad Massumi, Jöns Hilborn, Katarina Leblanc, Ayyoob Arpanaei and Peetra U MagnussonFatemeh Ajalloueian, Moa Fransson, Hossein Tavanai, Mohammad Massumi, Jöns Hilborn, Katarina Leblanc, Ayyoob Arpanaei and Peetra U Magnusson
  
  We compared the viability, proliferation, and differentiation of human Mesenchymal Stromal Cells (MSC) after culture on poly(lactic-co-glycolic acid) (PLGA) and PLGA/chitosan (PLGA/CH) hybrid scaffolds. We applied conventional and emulsion electrospinning techniques, respectively, for the fabrication of the PLGA and PLGA/ CH scaffolds. Electrospinning under optimum conditions resulted in an average fiber diameter of 166 ± 33 nm for the PLGA/CH and 680 ± 175 nm for the PLGA scaffold. The difference between the tensile strength of the PLGA and PLGA/CH nanofibers was not significant, but PLGA/CH showed a significantly lower tensile modulus and elongation at break. However, it should be noted that the extensibility of the PLGA/CH was higher than that of the nanofibrous scaffolds of pure chitosan. As expected, a higher degree of hydrophilicity was see.. Read More»
  DOI: 10.4172/2155-9821.1000230

  Abstract PDF