Nuclear Medicine & Radiation Therapy

Mohamed A. Bahri

Publications

• Research Article
  Biodistribution of Novel 68Ga-Radiolabelled HER2 Aptamers in Mice
  Author(s): Marlies Gijs, Guillaume Becker, Alain Plenevaux, Mohamed A. Bahri, An M. Aerts, Nathalie R.E.N. Impens, Sarah Baatout and André LuxenMarlies Gijs, Guillaume Becker, Alain Plenevaux, Mohamed A. Bahri, An M. Aerts, Nathalie R.E.N. Impens, Sarah Baatout and André Luxen
  
  Background: Two novel HER2 aptamers were recently selected with great potential for the in vitro diagnosis of HER2-positive cancer. The goal of this study was to examine the in vivo diagnostic potential of these HER2 aptamers. Methods: Both HER2 aptamers were radiolabelled with 68Ga, injected in mice bearing a HER2-positive and HER2-negative tumour and evaluated by PET/MRI. Results: Ex vivo bio distribution analysis revealed high uptake in the blood, tissues and organs, except the brain. Interestingly, this high uptake was explained by the slow blood clearance due to non-specific aptamer binding to blood proteins. We observed accumulation of radioactivity in both tumours in time. Although higher uptake in the HER2-positive tumour compared to the HER2-negative tumour was observed, this was accompanied with more necrosis in the HER2-negative tumour, which was observed by 18FDG PET/CT. C.. Read More»
  DOI: 10.4172/2155-9619.1000300

  Abstract PDF