Medicinal Chemistry

Mohamed Albarrati

Publications

• Research Article
  Design, Synthesis, Molecular Modelling and Biological Evaluation of Novel α-Naphtholhydroxamate Derivatives as Potential Anticancer Agents
  Author(s): Adel S Abdelrahim, Syam Mohan, Mohamed Albarrati, Hafiz Makeen and Safhi MMAdel S Abdelrahim, Syam Mohan, Mohamed Albarrati, Hafiz Makeen and Safhi MM
  
  Chemotherapy is one of the treatment options for cancer. A major problem in cancer chemotherapy is the lack of selective toxicity of many commonly used anti-cancer agents towards tumor tissue compared to normal tissue. Studies have shown that α-naphthol is selectively toxic to cultures of human tumor tissue compared to normal tissues in vitro. Hence, this study was conducted to synthesize a series of new hydroxamate derivatives containing α-naphthol nucleus by the reaction of naphthol acetic acid with amino acid methyl ester derivatives which were directly reacted with hydroxyl amine at room temperature. Structures of these compounds were confirmed by standard studies of IR, 1H NMR, 13 CNMR, MS and elemental analysis. The cytotoxicity of the synthesized compounds were studied using the MTT assay in four human cancer cell lines, including HepG2, PC-3, HT-29 and MCF-7. Among.. Read More»
  DOI: 10.4172/2161-0444.1000415

  Abstract PDF