Egypt
Research Article
Effect of Stem Cell Therapy on Gentamicin Induced Testicular Dysfunction in Rats
Author(s): Mohamed SM, ElHawary NM, Mohamed SF, Hashim NI, Saleh SY, Bakeer MR and Sawiress FAMohamed SM, ElHawary NM, Mohamed SF, Hashim NI, Saleh SY, Bakeer MR and Sawiress FA
Infertility is a worldwide problem affecting couples that have unprotected intercourse, so the current study investigated the possible ameliorative effect of intra testicular stem cell injection in rats subjected to Gentamycin gentamicin induced testicular degeneration. For this study 100 male rats were randomly allocated into 4 groups, namely, the control group (group I), gentamicin group (group II), stem cell group (group III) and gentamicin and stem cell group (group IV). Gentamicin was administered daily for 2 weeks (80 mg/kg) to groups (II and IV). Stem cells were injected intra testicular into rete testis once by the end of gentamicin administration in group (IV) or after I/P injection of saline in group III. Blood and testicular samples were collected by the end of weeks 2, 6 and 10 from group (I) and (II), and by the end of weeks 6 and 10 from group (III and IV). The obtained .. Read More»
DOI:
10.4172/2157-7420.1000263
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