Molecular Biomarkers & Diagnosis

Mohammed Abdalaal

Publications

• Research Article
  Serum Concentrations of Interleukin-33 and its Soluble Receptor sST2 in Patients with Persistent Atrial Fibrillation
  Author(s): Wael Alkhiary, Mohammed Abdalaal and Amr El- SabbaghWael Alkhiary, Mohammed Abdalaal and Amr El- Sabbagh
  
  Objectives: Interleukin-33 (IL-33) is a new member of the IL-1 cytokine family, which is thought to be involved in the pathogenesis of various inflammatory diseases, through its soluble receptor ST2. There is increasing evidence that inflammation is a relevant player in structural atrial remodeling that represents the main mechanism for atrial fibrillation (AF) persistence. This study was designed to investigate the state of IL-33/ST2 axis serum concentrations in patients with persistent AF. Design and Methods: We investigated the concentrations of IL-33, its soluble ST2 receptors, and high-sensitivity C-reactive protein levels (hsCRP) in the sera of 92 patients with persistent atrial fibrillation, and 68 controls. Results: Serum concentrations of IL-33, sST2, and hsCRP were all significantly elevated in patients w.. Read More»
  DOI: 10.4172/2155-9929.1000235

  Abstract PDF