Journal of Clinical & Medical Genomics

Mohammed EH Badawy

Publications

• Research Article
  Association of Protein Tyrosine Phosphatase 1B (PTPN1) Gene Polymorphisms (1023C>A and 467T>C) With Type 2 Diabetes: A Case-Control Study
  Author(s): Amal MH Mackawy, Entisar Abd-Alfarag Ahmed and Mohammed EH BadawyAmal MH Mackawy, Entisar Abd-Alfarag Ahmed and Mohammed EH Badawy
  
  Background: Type 2 diabetes (T2D) is a heterogeneous disorder that results from a combination of environmental and genetic factors. Insulin resistance (IR) is the core defect in T2D. The molecular mechanisms underlying IR are poorly understood. Protein tyrosine kinases and Protein tyrosine phosphatase 1B (PTPN1) are important regulators of insulin signal transduction. The association of PTPN1single-nucleotide polymorphisms (SNPs) with traits related to T2D has been investigated. The aim of this study was to determine the association of 1023C>A and 467T>C gene polymorphisms with Type 2 diabetes and its related metabolic traits. Method: Polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) analyses were carried out to detect the 1023C>A and 467T>C variants of PTPN1 gene in 100 Egyp.. Read More»
  DOI: 10.4172/2472-128X.1000135

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