Molecular Biomarkers & Diagnosis

Mohammed Ichou

Publications

• Short Communication
  STEAP-1: A Potential Biomarker, Promising Target?
  Author(s): Choukri Elm’hadi, Hassan Errihani and Mohammed IchouChoukri Elm’hadi, Hassan Errihani and Mohammed Ichou
  
  STEAP1 is one of six-transmembrane epithelial antigen of prostate (STEAP) highly expressed in human prostate cancer and is up-regulated in multiple cancers, including bladder, colon, breast, Ewing and lung cancers. Immunohistochemical analysis demonstrates significant STEAP1 expression at the intercellular communication between adjacent cells suggesting that this antigen must be a channel, or a transport protein indicating its potential role in tumor cell intercellular communication increasing the potential of STEAP1 as a diagnostic, prognostic, prophylactic and/or therapeutic target for new immunotherapeutic strategies. In prostate cancer, overexpression relates adenocarcinoma and prostatic intraepithelial neoplasia scores suggest that STEAP1 could be involved in tumor initiation and progression and may be of clinical usefulness in early disease diagnosis. Also, STEAP1 can serve as a.. Read More»
  DOI: 10.4172/2155-9929.1000333

  Abstract PDF