Journal of Bioanalysis & Biomedicine

Mohit Kumar

Publications

• Research Article
  Pharmacophore Modeling of Furanosyl Borate Diester: An Attempt to Combat Antibiotic Resistance Induced Helicobacter pylori Quorum Sensing Mediated Peptic and Duodenal Ulcer
  Author(s): Mohit Kumar, Aaliya Naaz, Ankita Sharma, Deepak Teotia and Sisir NandiMohit Kumar, Aaliya Naaz, Ankita Sharma, Deepak Teotia and Sisir Nandi
  
  Helicobacter pylori is a gram-negative, microaerophilic bacterium found usually in the stomach of a person with chronic gastritis and gastric ulcers. More than 50% of the world’s population harbor H. pylori in their upper gastrointestinal tract. About 85% of people infected with H. pylori never experience symptoms or complications. Individuals with chronic gastritis and infected with H. pylori have a 10 to 20% lifetime risk of developing peptic ulcers, MALT lymphoma, the pathogenesis of gastric cancer and several extra-gastric diseases. No vaccines are developed yet and the bacterial antibiotic resistance has been a growing concern. Helicobacter pylori produce virulence and antibiotic resistance through quorum sensing mechanisms by generating AI-2. Inhibition of quorum sensing would be a novel approach for the effective treatment of a.. Read More»
  DOI: 10.4172/1948-593X.1000218

  Abstract PDF