Molecular Biology: Open Access

Mona Gamal Elgazzaz

Publications

• Research Article
  Association of Vitamin D Receptor Gene Polymorphisms and Type1 Diabetes in an Egyptian Population
  Author(s): Mona Gamal Elgazzaz, Eman Abd-ElMoemen Mohammed, Hoda Ahmed Atwa and Fouad Mohamed BadrMona Gamal Elgazzaz, Eman Abd-ElMoemen Mohammed, Hoda Ahmed Atwa and Fouad Mohamed Badr
  
  Aim and background: Vitamin D is known for its immune modulatory functions and its role in normal insulin secretion. Vitamin D acts via vitamin D receptor gene (VDR). The study was conducted to assess the relationship between Apa I and Taq I restriction site polymorphisms of vitamin D receptor gene and type1 diabetes in an Egyptian population. Subjects and Methods: One hundred Egyptian participants (1-20 years old) of both sexes were recruited in this study. Fifty of them were type 1 diabetes patients and the other fifty were control non diabetic subjects. Apa I and Taq I variations were tested using Polymerase Chain Reaction and Restriction Fragment Length Polymorphism. Results: Genetic analysis revealed that AA and Tt genotypes were predominant in the two study groups with higher frequency among patients group, where.. Read More»
  DOI: 10.4172/2168-9547.1000171

  Abstract PDF